Community-based randomized controlled trial on risk reduction for cardiovascular disease by therapeutic life-style change

进行了随机对照一级预防研究，以增加体力活动和治疗性生活方式的改变，以降低40至69岁绝经期男性和女性无症状居民的心血管疾病风险和促进健康。研究对象共316名，随机分为对照组（A组105名）和干预组（B=运动组106名，C=运动加饮食组105名）。作为一种治疗性的生活方式改变，每周增加150分钟的快走的体力活动，建议B和C组。C组在此基础上进行营养指导，包括理想体重下的最佳能量摄入、n-3多不饱和脂肪酸摄入量增加至2.9g/d、膳食纤维增加2.0g/d。所有参与者的快步行走通过计步器监测，该计步器能够记录至少超过10分钟的连续快步行走。每月向干预组提供关于治疗性生活方式改变的新闻信件和讲座。1年后，重新评估风险特征，结果所有组的BMI、血清甘油三酯浓度降低，HDL-胆固醇水平升高。运动组（B & C）的体力活动显著增加。对正常人群进行健康教育的干预性研究使干预组的体力活动增加，并改善了各组的血脂风险状况。

The randomized controlled primary prevention study to introduce increased physical activity and therapeutic life-style changes was carried out to reduce risk profile for cardiovascular disease and health promotion to asymptomatic habitants, male and female with menopause, aged 40 to 69 years old. A total of 316 habitants were recruited with informed consent, and allocated into three groups consisting control (A: 105) and interventional groups (B=exercise; 106, C=exercise with diet; 105). As a therapeutic life-style change, increased physical activity of 150 minutes brisk walking per week was recommended to B and C groups. In addition, nutritional instruction consisting of optimal energy intake for ideal body weight, increased intake of n-3 ploy-unsaturated fatty acid up to 2.9g a day and additional increase of dietary fiber by 2.0g more than ever were recommended to C group. Brisk walking of all participants was monitored by pedometer which enables to record at least more than 10 minutes continuous brisk walking. News letters and lectures on therapeutic life-style changes were provided to the interventional groups every month. After 1 year, risk profile was re-evaluated, resulting reduction of BMI, serum concentration of triglyceride and increased HDL-cholesterol levels in all groups. Physical activity was significantly increased in exercise groups (B ＆ C). The interventional study with health education for normal population induced increased physical activity in the interventional groups and ameliorated lipids risk profile in all groups.