Synthetic Studies on Semiochemicals for the Control of Agricultural Pests

已经完成了以下生物活性天然产物的全合成：(1)enokipodins A，B，C和D(由食用菌金针菇产生的高度氧化的α-铜绿烯酮型倍半萜类化合物)；(2)翼状酸A和B(具有从植物附生放线菌链霉菌TP-A0451中分离出来的具有独特的螺环多酮结构的有效植物生长促进剂)；(3)Taboxinine-β-lactom(由病原体Pusomonas syringae PV产生的一种植物毒素)。(5)果蝇、果蝇和苍蝇的主要性信息素成分；(6)群落A、B、C、D、E、F和H(由共生真菌Podospora Commis产生的抗微生物代谢产物)；(7)吡喃醇(由稻瘟菌Magnaporthe grisea产生的植物毒素)；(8)Gizzerosine(热处理鱼粉中含有的对雏鸡的gizzard侵蚀有效的诱导剂)；(9)诱导细胞凋亡的多不饱和脂肪酸；(10)抗HIV倍半萜醇A和B(含由多年生灌木LitSea verticillata产生的新的碳素描记物)。合成了白化链霉菌产生的菌丝体诱导代谢产物帕霉素635A和植物生长抑制剂植物生长抑制剂elaiophylin。此外，还研究了印楝素的全合成方法。印木素是印楝树中含有的一种有效拒食剂。

The total synthesis of the following biologically active natural products have been accomplished : (1)enokipodins A,B,C, and D (highly oxygenated a-cuparenone-type sesquiterpenoids exhibiting antimicrobial activity produced by the edible mushroom, Flammulina velutipes) ; (2)pteridic acids A and B (potent plant-growth promoters possessing unique spirocyclic polyketidic structures isolated form the phytoepiphytic actinomycete, Streptomyces hygroscopicus TP-A0451) ; (3)tabtoxinine-β-lactom (a phytotoxin produced by the pathogen Pseudomonas syringae pv. tabaci) ; (4)pteroenone (a defensive metabolite of the pteropod, Clione antarctica) ; (5)the major sex pheromone components of the fruit flies, Drosophila ananassae and D.pallidosa ; (6)communiols A,B,C,D,E,F,and H (antimicrobial metabolites produced by the coprophilous fungus, Podospora communis) ; (7)pyricuol (a phytotoxin produced by the rice blast fungus, Magnaporthe grisea) ; (8)gizzerosine (a potent inducer of gizzard erosion in chicks contained in heat-treated fish meal) ; (9)apoptosis-inducing polyunsaturated conjugated fatty acids ; (10)litseaverticillols A and B (anti-HIV sesquterpenoids bearing a novel carbon sketeton produced by the perennial shrub, Litsea verticillata). Partial syntheses of pamamycin-635A (an arerial mycelium-inducing metabolite produced by Streptomyces alboniger) and elaiophylin (an antibiotic as well as a plant-growth inhibitor) were conducted. Studies directed toward the total synthesis of azadirachtin (a potent antifeedant contained in the neem tree, Azadirachta indica) was also made.