A cohort study on cancer mortality among Chinese iron-steel workers

在本研究的两个目标中，第二次中国钢铁工人跟踪调查由于1994年以来中国钢铁公司的重组和裁员，身份证号码和人事管理制度的彻底改变而无法进行，因此不可避免地暂停并最终放弃。尽管与中国研究人员讨论了几种替代方法，例如对原始子队列的随访。另一个目的，即，在最初的队列中重新分析了暴露于15种有害物质的死亡风险。对总共121，846名男性和25，216名女性的进一步分析提供了一些有意义的结果。结果表明，鞍山市钢铁环境中的总死亡率、癌症死亡率及其他死亡率的SMR（standardized mortality ratio）均随钢铁环境暴露水平的升高而升高，但由于健康工人的影响，SMR均显著低于零值。对所有死亡率、癌症死亡率和几个癌症部位的标准化危险比（SRR）表明，钢铁铸造厂接触这些因素的工人的死亡风险高于无任何接触这些因素的蓝领工人。特别是，联合暴露于多环芳烃（PAH）等多种因素的工人显示，所有死亡率、癌症死亡率、脑血管和心血管死亡率的SRR显著较高。与美国、英国、巴西等国的文献相比，本研究具有队列规模大、随访率高（98.1%）、研究对象为女工等特点，在职业卫生领域具有重要的应用价值。(Two在学术期刊上发表的文章和在科学会议上发表的10篇研究报告）（281字）

Of two aims in this study, the second follow-up of Chinese iron-steel workers had to be inevitably suspended and consequently given up because the iron-steel company had been restructured and downsized since 1994 with the current of the times in China The ID number and personnel management system was totally changed and made it unable to be conducted., although several alternative methods were discussed with Chinese researchers such as a follow-up of sub-cohort of the original. The other purpose, i.e., mortality risk of exposures to fifteen hazardous agents was re-analyzed in the original cohort Further analyses with a total of 121, 846 males and 25, 216 females provide some meaningful results. SMR (standardized mortality ratio) for all mortality, cancer mortality and others showed increasing trend with the levels of exposure to iron-steel environment with reference to the general population in Anshan, China, although SMRs were significantly lower than null value because of the healthy workers effect. SRR (standardized risk ratio) for all mortality, cancer mortality and several sites of cancer indicated higher mortality risks among the workers with exposure to factors in iron-steel foundry with reference to the blue-collar workers without any exposures to the factors. In particular, the workers with combined exposure to several factors included PAH (polycyclic aromatic hydrocarbons) showed significantly higher SRRs for all mortality, cancer mortality, cerebrovascular and cardiovascular mortality. Compared with previous reports in US, UK, and Brazil, the characteristics in the study were larger in scale of the cohort, higher rate of follow-up (98.1%), and providing the results in female workers, which may be of great value in occupational health field. (Two publications in academic journals and ten research presentation in scientific meetings were included) (281 words)