Surface modification for Bio-Metallic Materials for Prevention of Harmful ion Dissolution under Dynamic loading

在细胞培养条件下，采用常规极化测量方法对金属生物材料的生物相容性进行了电化学表征。金属材料的表面改性，包括不锈钢、镍钛合金、氧化钛及其合金以及导电聚合物。研究了304型和316L型不锈钢在Hanks溶液、Eagle最小基本培养基（MEM）、不含细胞的含血清培养基（MEM含10%胎牛血清）和含细胞的含血清培养基中一周的电化学腐蚀行为。极化电阻测量表明，不锈钢耐汉克斯和MEM溶液。在汉克斯和MEM溶液中，304型比316L型的点蚀性能更差。用R_p测定不锈钢在培养基中的均匀耐蚀性低于Hanks和MEM。由于表面钝化膜的保护作用较弱，具有较高的阳极溶解率，因此具有较高的耐离子性。当电池存在时，初始耐腐蚀性较低；但三天后逐渐增加，与小区覆盖率趋势一致。发现电池的存在抑制了阴极反应，即氧还原，从而提高了均匀耐腐蚀性。另一方面，304型和316L型不锈钢在被细胞覆盖时更容易受到点蚀。钛及钛基合金具有模拟体液环境下的连续电化学监测和快速应变电极技术。检测的材料为Ti、Ti- 6ai - 7nb、Ti- 6ai - 4v和Ti- 29nb - 13ta -4.6 zr。灭菌后的标本浸泡在Hanks液或Eagle's minimum essential medium （MEM）溶液中。同时连续测量电极电位和极化电阻7天。对于所有检测的试样，两种溶液的腐蚀电位在2天内达到稳定状态。另一方面，在检测期间，耐蚀性单调增加。少

The bio compatibility of metallic biomaterials are characterized electrochemically using conventional polarization measurements under cell culturing condition, a rapid straining electrode technique. The surface modification of metallic materials including stainless steels, Ni-Ti alloy, Ti and its alloys with oxide formation and also electroconductive polymers.The electrochemical corrosion behavior of Type 304 and 316L stainless steels was studied in Hanks' solution, Eagle's Minimum Essential Medium (MEM), serum containing medium (MEM with 10% of fetal bovine serum) without cells, and serum containing medium with cells over a one-week period. Polarization resistance measurements indicated that the stainless steels were resistant to Hanks' and MEM solutions. Type 304 was more inferior to pitting corrosion than Type 316L in Hanks' and MEM solutions. The uniform corrosion resistance of stainless steels, determined by R_p, was lower in culturing medium than in Hanks' and MEM. The low corros … More ion resistance was due to surface passive film with less protective to reveal high anodic dissolution rate. When cells were present, the initial corrosion resistance was low; but gradually increased after three days, consistent with the trend of cell coverage. The presence of cell was found to suppress the cathodic reaction, that is, oxygen reduction, and increase the uniform corrosion resistance as a consequence. On the other hand, both Type 304 and 316L stainless steels become more susceptible to pitting corrosion when they were covered with cells.Ti and Ti based alloys are characterized by a continuous electrochemical monitoring and a rapid straining electrode technique in simulated body fluid environment. Materials examined are Ti, Ti-6AI-7Nb, Ti-6AI-4V and Ti-29Nb-13Ta-4.6Zr. Sterilized specimens were immersed in Hanks solution or Eagle's minimum essential medium (MEM) solution. Electrode potential and polarization resistance were simultaneously and continuously measured up to 7 days. For all the specimens examined, the corrosion potential reached to a steady state in 2 days for both solutions. On the other hand, corrosion resistance increased monotonously for the period examined. Less