Research for Antitumor Crude Drug from Malaysian Unutilized Plant Resorces

马来西亚位于东南亚，拥有世界上最古老和最丰富的植物群之一。马来西亚气候常年温暖，几乎均匀，适合热带雨林的生长。马来西亚森林是相当独特的，因为它是北部亚洲大陆（从东印度延伸到印度支那）和南部马来西亚植物（延伸到所有马来群岛）之间两大植物群的主要迁徙路线。从马来亚植物区系中收集植物，并对其提取物进行了生物活性测试，这些提取物分别属于Meliaceae、leguminoaceae和Apocynaceae。从这些研究中，许多细胞毒性和抗疟原虫化合物被分离出来并进行了化学表征。从红carpus中分离到5个新的类柠檬素，红carpus A- e和A、B、D-seco七环骨架，它们对P-388小鼠白血病细胞具有细胞毒性。Cassiarins A和Cassiarins B是一种新型芳香生物碱，具有前所未有的三环骨架和有效的抗疟原虫活性，已被广泛用于治疗周期性发热和疟疾。Huncaniterine A是一种新的双吲哚类生物碱，其n -氧化物部分由堇青素型和蛇皮藻型骨架组成，对离体大鼠主动脉环具有中等的血管松弛活性。

Malaysia is situated in South East Asia, has one of the oldest and the richest flora in the world. Malaysia has a climate, which is constantly warm, and nearly uniform suitable for the growth of tropical rainforests. Malaysian forest is rather unique in the sense that it serves as a major migratory track for two great floras between the continental Asiatic(extending form Eastern India to Indochina) in the north and the Malaysian flora(extending to all the Malay Archipelago) in the south.Plants were collected from the Malayan flora and their extracts from plants belonging to Meliaceae, Leguminosae, and Apocynaceae were tested for bioactivity. From these studies, a number of cytotoxic and antiplasmodial compounds were isolated and characterized chemically.Five new limonoids, erythrocarpines A-E belonging to mexicanolide-type and A, B, D-seco heptacyclic skeletons were isolated from Chisocheton erythrocarpus, which showed cytotoxicity against P-388 murine leukemia cells. Cassiarins A and B, novel aromatic alkaloids with an unprecedented tricyclic skeleton and potent antiplasmodial activity have been isolated from the leaves of Cassia siamea(Leguminosae), which have been widely used for the treatment of periodic fever and malaria. Huncaniterine A, a new bisindole alkaloid with an N-oxide moiety consisting of corynantheine-type and aspidosperma-type skeletons, which exhibited a moderate vasorelaxant activity on isolated rat aorta ring, has been isolated from the bark of Hunteria zeylanica collected in Kampung Padang, Malaysia.