Physiological and biochemical research for improvement of physical function in the elderly-Effect of concomitant treatment with exercise therapy and diet therapy-

老年人身体机能下降，老年人有许多慢性病。治疗疾病和改善条件是老年人保持健康的必要条件。【研究1】对老年退行性痴呆患者的生理生化特征进行调查。【2】运动疗法的影响研究在老年人和去适应作用【3】研究老年人的膳食补充剂对退化的影响【2】Misasa医学中心研究温泉和慢性呼吸道疾病患者有温泉疗法在我们医院之前的研究表明,主观症状和改善通气功能spa治疗慢性阻塞性肺疾病(COPD)患者因为温泉疗法改善黏膜纤毛的清除和呼吸功能障碍。我们研究了spa疗法对COPD患者6分钟步行距离的影响。我们发现水疗疗法改善了COPD患者的Borg评分和6分钟步行距离。结果表明，水疗疗法可能导致COPD患者更好的运动耐受性。[研究3]我们报道了水疗疗法联合膳食补充紫苏籽油对哮喘患者有效，并可抑制外周血白细胞生成白三烯C4 （LTC4）。然而，结合水疗疗法和膳食补充紫苏籽油对支气管哮喘病理生理的影响尚不清楚。本研究通过观察紫苏籽油对哮喘患者血清嗜酸性阳离子蛋白（ECP）水平的影响，探讨其对支气管哮喘的治疗作用。本研究结果表明，水疗疗法联合膳食补充紫苏籽油可降低LTC_4和ECP，改善肺功能和哮喘控制。

Physical function decreases in the elderly and the elderly have many chronic diseases. Treatment fur diseases and improvement of deconditioning is necessary for keeping health in the elderly. We investigated 【Research 1】 physiological and biochemical characteristics in the elderly with deconditioning, 【Research 2】 the effects of exercise therapy on deconditioning in the elderly and 【Research 3】 the effects of dietary supplementation on deconditioning in the elderly【Research 2】 Misasa Medical Center has spa and patients with chronic respiratory disease have spa therapy in our hospital Our previous studies have shown that subjective symptoms and ventilatory function are improved by spa therapy in patients with chronic obstructive pulmonary disease (COPD) because spa therapy improved mucociliary clearance and ventilatory dysfunction. We investigated the effects of spa therapy on six-minute walk distance in patients with COPD. We found that spa therapy improved Borg scale and six-minute walk distance in patients with COPD. The results demonstrated that spa therapy may lead to better exercise tolerance in patients with COPD.[Research 3] We have reported that spa therapy combined with dietary supplementation of perilla seed oil would be effective for patients with asthma, and would suppress the generation of leukotriene C4 (LTC4) by peripheral leucocytes. However, it is still unclear how the combination spa therapy and dietary supplementation of perilla seed oil influences on the pathophysiology of bronchial asthma. In the present study, the effects of spa therapy combined with dietary supplementation of perilla seed oil were examined in patients with asthma in relation to the serum eosinophil cationic protein (ECP) levels to investigate the effect on bronchial asthma. The results obtained here suggest that spa therapy combined with dietary supplementation of perilla seed oil leads to decrease in LTC_4, and ECP and improves pulmonary function and asthma control.