Portable Noninvasive Positive Airway Device for COPD Patient Therapy

用于 COPD 患者治疗的便携式无创正压气道装置

• 批准号: 10081908
• 负责人: Robert J Knuesel
• 金额: $ 25.18万
• 依托单位: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10081908
• 关键词: Activities of Daily Living; Acute; Adopted; Age; Air; Biomedical Technology; Blood; Breathing; Carbon Dioxide; Cause of Death; Chairperson; Charge; Chest; Chronic; Chronic Obstructive Airway Disease; Clinical; Clinical Research; Clinical Trials; Collaborations; Computer software; Consult; Critical Care; Data Management Resources; Data Reporting; Development; Devices; Diagnosis; Disease; Distress; Doctor of Philosophy; Dyspnea; Economic Burden; Emergency Situation; Ensure; Evaluation; Exercise; Exercise Tolerance; Exertion; Fright; Health; Health behavior; Hospitalization; Human; Intervention; Intervention Studies; Lip structure; Lung diseases; Mechanics; Medicine; Mental Depression; Miniaturization; Modality; Muscle; Office Visits; Operative Surgical Procedures; Pathway interactions; Patients; Perception; Peripheral; Phase; Physical activity; Physiological; Play; Population; Principal Investigator; Recurrence; Research; Research Personnel; Resources; Respiration; Risk; Role; Route; Scientist; Self Management; Small Business Innovation Research Grant; Social isolation; Symptoms; System; Systems Development; Techniques; Touch sensation; Training; Unconscious State; United States; Universities; Ventilator; Work of Breathing; base; common symptom; deconditioning; design; exercise training; experience; improved; innovation; mange; miniaturize; new technology; novel; phase 2 testing; portability; pressure; prevent; prospective; prototype; pulmonary rehabilitation; respiratory; sedentary; sedentary lifestyle; trend; usability; ventilation

Abstract Koronis Biomedical Technologies proposes to develop and fully evaluate a novel, on-demand handheld bi-level positive airway pressure (BiPAP) ventilator to treat Chronic Obstructive Pulmonary Disease (COPD) patients suffering from exertional dyspnea (“breathlessness”). It is well known that dyspnea trends severe COPD patients as they age towards inactivity, resulting in peripheral muscle deconditioning that further increases the risk of experiencing dyspnea, establishing a vicious cycle of recurrent fear of dyspnea, further inactivity and potential social isolation. The proposed Bi-level Rapid Emergency Airway THErapy (BREATHE) system will be optimized to provide proven BiPAP therapy to rapidly relieve acute dyspnea in a miniaturized, portable handheld form factor. This system will allow for therapy on the go, untethering the patient and increasing their confidence to engage in activities of daily living.

摘要