Portable Noninvasive Positive Airway Device for COPD Patient Therapy

用于 COPD 患者治疗的便携式无创正压气道装置

基本信息

批准号：
10081908
负责人：
Robert J Knuesel
金额：
$ 25.18万
依托单位：
KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10081908
关键词：
Activities of Daily Living Acute Adopted Age Air Biomedical Technology Blood Breathing Carbon Dioxide Cause of Death Chairperson Charge Chest Chronic Chronic Obstructive Airway Disease Clinical Clinical Research Clinical Trials Collaborations Computer software Consult Critical Care Data Management Resources Data Reporting Development Devices Diagnosis Disease Distress Doctor of Philosophy Dyspnea Economic Burden Emergency Situation Ensure Evaluation Exercise Exercise Tolerance Exertion Fright Health Health behavior Hospitalization Human Intervention Intervention Studies Lip structure Lung diseases Mechanics Medicine Mental Depression Miniaturization Modality Muscle Office Visits Operative Surgical Procedures Pathway interactions Patients Perception Peripheral Phase Physical activity Physiological Play Population Principal Investigator Recurrence Research Research Personnel Resources Respiration Risk Role Route Scientist Self Management Small Business Innovation Research Grant Social isolation Symptoms System Systems Development Techniques Touch sensation Training Unconscious State United States Universities Ventilator Work of Breathing base common symptom deconditioning design exercise training experience improved innovation mange miniaturize new technology novel phase 2 testing portability pressure prevent prospective prototype pulmonary rehabilitation respiratory sedentary sedentary lifestyle trend usability ventilation

项目摘要

Abstract Koronis Biomedical Technologies proposes to develop and fully evaluate a novel, on-demand handheld bi-level positive airway pressure (BiPAP) ventilator to treat Chronic Obstructive Pulmonary Disease (COPD) patients suffering from exertional dyspnea (“breathlessness”). It is well known that dyspnea trends severe COPD patients as they age towards inactivity, resulting in peripheral muscle deconditioning that further increases the risk of experiencing dyspnea, establishing a vicious cycle of recurrent fear of dyspnea, further inactivity and potential social isolation. The proposed Bi-level Rapid Emergency Airway THErapy (BREATHE) system will be optimized to provide proven BiPAP therapy to rapidly relieve acute dyspnea in a miniaturized, portable handheld form factor. This system will allow for therapy on the go, untethering the patient and increasing their confidence to engage in activities of daily living.

抽象的 Koronis生物医学技术提案，以开发和充分评估一种新颖的按需手持式双层阳性气道压力（BIPAP）通风tor治疗慢性阻塞性肺疾病（COPD）患者患有劳累的呼吸困难（“呼吸困难”）。众所周知，呼吸困难趋势严重COPD 随着患者的衰老年龄，导致周围肌肉的调解，从而进一步增加了发生呼吸困难的风险，建立一个奇妙的反复恐惧呼吸困难的循环，进一步的不活动和潜在的社会隔离。拟议的双层快速紧急气道治疗（呼吸）系统将是优化以提供经过验证的BIPAP疗法，以快速挽救微型，便携式的急性呼吸困难手持式外形。该系统将在旅途中进行治疗，使患者缠绕并增加他们的有信心从事日常生活活动。