Assessment of sensitive obesity animal models for dietary manipulation and investigation of dietary components with anti-obesity effects

1. C57BL/6J小鼠（a野生型；+/+）的饮食诱导反应：为了收集ob异源型小鼠（ob/+）的背景数据，我对野生型（+1+）小鼠的饮食诱导反应进行了研究。因此，在野生型小鼠（+1+）中，高脂饮食增加了腹部脂肪的积累，但认为脂肪组织的功能没有受到显著影响。ob异型瘦素敲除小鼠（ob/+）与野生型小鼠（+/+）的饮食诱导反应比较：通过ob/+与+/+雄性小鼠的饮食诱导反应比较，对两种小鼠模型进行了灵敏的饮食诱导反应观察。上述结果表明，高脂饮食对小鼠的影响强于基因型。3 .异型（ob/+）和野生型（+/+）小鼠功能性食品成分的评价：结果表明，大豆和大豆均对腹腔脂肪细胞增大有抑制作用。db异型瘦素受体敲除小鼠（db/+）与野生型小鼠（+/+）的饮食诱导反应比较：我用配种方法将db/+小鼠与C57BL/6J小鼠背景杂交，比较饮食诱导反应。因此，db/+和+/+小鼠之间的差异是显著的，并且在高脂肪饮食中观察到与正常饮食相比的显著差异。对STR/Ort小鼠作为新型肥胖模型小鼠的评价：通过对发生天然小鼠骨关节炎的STR/Ort小鼠的评价，发现正常饮食容易发生腹部脂肪性肥胖，对高脂饮食的敏感性优于C57BL/6J小鼠。C57BL/6J和KK/Ta小鼠的功能性食品成分评价：我对C57BL/6J和KK/Ta小鼠的功能性食品成分进行了评价，认为根据研究目的选择合适的模型，使KK/Ta小鼠与C57BL/6J小鼠对饮食的反应有所不同。少

1. Diet induced response in C57BL/6J mice (a wild type ; +/+) : I examined the diet induced response in the wild type (+1+) mice for the purpose of collecting the background data of the ob hetero type mice (ob/+). As a result, in wild type mice (+1+), the high fat diet increased abdominal fat accumulation, but it was thought that the function of adipose tissues was not influenced significantly.2. Comparison of diet induced response between ob hetero type of the leptin knockout mice (ob/+) and the wild type mice (+/+) : As a result of comparison of the diet induced response between ob/+ and +/+ male mice, both mice models were observed diet induced response sensitively. These results suggested that influence of the high fat diet was stronger than the genotype in this mouse model.3. Evaluation of the functional food ingredients in hetero type (ob/+) and wild type (+/+) mice : As a result, inhibitory effect of the enlargement of the abdominal adipocyte was observed in the both of soy bean … More phospholipids and egg yolk phospholipids evaluated.4. Comparison of diet induced response between db hetero type of the leptin receptor knockout mice (db/+) and the wild type mice (+/+) : I bred the db/+ mice with a background of C57BL/6J mice with a mating method and compared the diet induced response. As a result, a difference between db/+ and +/+ mice was significant, and the marked difference was observed in the high fat diet compared to that in the normal diet.5. Evaluation of the STR/Ort mice as the novel obesity model mice : As a result of having evaluated the STR/Ort mice which develop natural murine osteoarthritis, it was easy to develop the abdominal fat obesity in the normal diet, and the sensitivity for the high fat diet was better than the C57BL/6J mice.6. Evaluation of the functional food ingredients in C57BL/6J and KK/Ta mice : I evaluated the functional food ingredients in C57BL/6J and KK/Ta mice It was thought that adequate model should be chosen depending on a purpose of the research so that a KK/Ta mouse was different from a C57BL/6J mouse in the response to the diet. Less