Kingdom switching microbial pathogens: the bioinformatics of mutation in the genomes of viruses and bacteria affecting crops, livestock and people.

一些引起传染病的生物在植物和脊椎动物之间移动，要么是最近的，要么是随着进化时间的推移反复移动的。植物和脊椎动物之间的切换强烈影响这些微生物的突变和进化方式。我们将在基因组序列数据库中搜索有关宿主的选择如何影响病毒和细菌基因组突变的信息，并对所涉及的进化过程进行建模。这个项目将促进我们对微生物基因组的精细结构和基因选择压力的重要性的理解。它将为人类以及国内农作物和牲畜带来更好的疾病管理战略。

Some organisms that cause infectious diseases have moved between plants and vertebrates, either recently or repeatedly over evolutionary time. Switching between plants and vertebrates strongly influences the way these microbes mutate and evolve. We will search the genomic sequence databases for information about how the choice of host influences mutations in viral and bacterial genomes and model the evolutionary processes involved. This project will advance our understanding of the fine structure of microbial genomes and the importance of selection pressures on genes. It will lead to better disease management strategies for humans, and for domestic crops and livestock.