Research of the oxygen and glucose metabolism and their relationship in hepatic tumors with positron emission computed tomography

即使在恶劣的环境中，恶性肿瘤也会重复细胞分裂和活跃的增殖。因此，糖酵解途径被认为在很大程度上有助于获得细胞增殖的能量。换句话说，无氧葡萄糖代谢不是在正常组织中得到极大促进，而是在恶性肿瘤中得到极大促进。使用18F-氟代脱氧葡萄糖(FDG)进行正电子发射计算机断层扫描(PEI)检查就是应用这一现象。尽管肿瘤良恶性的鉴别诊断和侵袭区的界定很困难，但FDG-PET通过影像研究使定性诊断成为可能。另一方面，FDG-PET可以定量评价肿瘤的糖代谢。尽管FDG-PET在恶性肿瘤中的检出率很高，但在转移性肝肿瘤中，FDG-PET的检出率却极低。人们认为，肝细胞癌(HCC)与其他癌症的根本区别在于它们的血液供应。肝细胞癌富含bl…。肿瘤血管比其他肿瘤多，血液供应充足。换句话说，人们认为肝细胞癌的葡萄糖代谢是活跃的。FDG-PET是无氧糖代谢的指标，FDG-PET阴性图像提示有氧代谢。也就是说，预计肿瘤的血流与无氧葡萄糖代谢率(FDG-PEI的检测率)呈负相关。本研究的目的是阐明肝癌在FDG-PET中检出率低的原因。肿瘤的血供与无氧糖代谢之间的关系似乎比肿瘤的种类普遍。结果表明，无氧糖代谢与肝细胞癌的血流量和耗氧量有关，也与其他恶性肿瘤的耗氧率有关。在恶性肿瘤中，氧缺乏与有效氧耗量(氧耗率)升高是相辅相成的，而在肝细胞癌中，氧缺乏与血流量增加是相辅相成的。较少

Malignant tumors repeat cell division and also proliferation actively even in bad environment. Consequently, it is thought that the glycolytic pathway largely contributes to getting energy for cell proliferation. In other words, anaerobic glucose metabolism is greatly facilitated not in normal tissue but in malignant tumor. Examination with positron emission computed tomography (PEI) using 18F-fluorodeoxygluoose (FDG) is to apply this phenomenon. Even though differential diagnosis which the tumor is benign or malignant and definition of invasive area are difficult, FDG-PET makes qualitative diagnosis possible by imaging study. On the other hand, FDG-PET enable quantitative evaluation of tumor glucose metabolism Detection rate by FDG-PET is extremely low in hepatocellular carcinoma (HCC), although it in malignant tumor is high even in metastatic liver tumor. It is thought that fundamental differences between (HCC) and the other cancer are due to their blood supply. HCC is rich in the bl … More ood vessels than the other cancer and it blood supply is abundant. In other words, it is thought that glucose metabolism is active in HCC. FDG-PET is indicator of anaerobic glucose metabolism and negative image of FDG-PET indicate to aerobic metabolism. Namely, it is expected that there is inverse correlation between blood flow in the cancer and anaerobic glucose metabolic rate (detection rate of FDG-PEI).The purpose of this research is to clarify the reason of low detection rate of HCC in FDG-PET.The relationship between the blood supply and anaerobic glucose metabolism of the tumor seem to be universal exceeding the kind of neoplasm. As results, anaerobic glucose metabolism related to blood flow and oxygen consumption in HCC, and also it related to oxygen consumption rate in other malignant tumors. It was thought that xygen deficiency is supplemented with elevation of effective oxygen consumption (oxygen consumption rate) in malignant tumors, but oxygen deficiency is supplemented with increase in blood flow in HCC. Less