A study on regional difference of reaction to trigeminal stimulation

伤害性刺激家兔三叉神经引起血压波动。我们观察了什么样的刺激使血压升高或降低，并观察了刺激过程中自主神经活动的变化。5 Hz刺激眶下神经引起降压反应，25 Hz刺激眶下神经引起升压反应。当血压下降时，观察到肾交感神经活动（RSNA）减少。另一方面，当血压下降时，观察到肾交感神经活动（RSNA）减少。另一方面，当血压升高时，观察到RSNA增加。提示刺激三叉神经引起的循环反应是一种躯体-交感神经反射，其传出通路为交感神经。接下来，我们研究了影响这些反应的因素。动脉压力感受性反射增强降压反应，抑制升压反应，抑制升压反应。异丙酚 ...更多信息 抑制升压反应，芬太尼抑制降压反应。异氟醚和酚妥拉明抑制升压和降压反应。结果提示，刺激三叉神经引起的降压和升压反应在延髓内存在不同的通路。此外，我们还检测了降压反应发生时颈总动脉（CA）、肾动脉（RA）和股动脉（FA）的血流量变化，并观察了芬太尼对各动脉血流量的影响。我们观察了刺激三叉神经和降低平均动脉压时血流量的变化。RA、FA、CA的变化依次较大，CA和FA的变化无显著性差异。提示交感神经活性和血流自我调节能力的降低程度存在地区性差异。虽然芬太尼使三叉神经刺激引起的血压下降幅度变小，但芬太尼对动脉血流量的区域差异没有影响。少

Nociceptive stimulation to trigeminal nerve of rabbit causes fluctuations in blood pressure. We examined what stimulation raised or lowered blood pressure and observed change of autonomic nervous activity during stimulation. Stimulation of infraorbital nerve with 5 Hz caused depressor response, stimulation with 25 Hz caused pressor response. When blood pressure fell, a decrease in renal sympathetic nerve activity (RSNA) was observed. On the other hand, when blood pressure fell, a decrease in renal sympathetic nerve activity (RSNA) was observed. On the other hand, when blood pressure rose, an increase in RSNA was observed. These results suggested that the circulatory response elicited by trigeminal stimulation was a somato-sympathetic nerve reflex whose efferent pathway was sympathetic nerve. Next, we examined the factors that influenced these responses. Arterial baroreflex enhanced the depressor response and inhibited the pressor response and inhibited the pressor response. Propofol in … More hibited the pressor response and fentanyl inhibited the depressor response. Isoflurane and phentolamine inhibited the pressor and depressor responses. These results suggested there were different pathways in medulla causing the depressor and pressor responses elicited by trigeminal stimulation. In addition, we examined the change in blood flow volume of arteria carotis communis (CA), arteria renalis (RA), and arteria femoralis (FA) when the depressor response occurred, and the influence of fentanyl on the blood flow volume of each artery was observed. We observed the change in the blood flow volume when trigeminal nerve was stimulated and mean arterial pressure was lowered. The change was large in order of RA, FA, and CA, and there was no significant difference in the change of CA and FA. These results suggested that there were regional differences in level of a decrease in sympathetic nerve activity and self-adjustment ability of the blood flow. Though a decrease in blood pressure by trigeminal stimulation became small by administering fentanyl, the regional differences of arterial flow volume did not be affected with fentanyl. Less