Mechanism of the beneficial effects of exercise training and lipid lowering drug therapy

测定了运动训练（Ex）和HMG-CoA还原酶抑制剂他汀类药物联合治疗的效果。雄性zucker -fat大鼠分为4组；对照组、阿托伐他汀（ATV）组、Ex组和联合治疗组（ATV+Ex）。10周后，两组血糖无明显差异。但ATV+Ex组低于对照组。Ex组和ATV+Ex组血浆总胆固醇较低。三个实验组的血浆甘油三酯均较低。血浆胰岛素、瘦素和脂联素在四组间无显著差异。-肝甘油三酯在Ex组和ATV+Ex组均较低，且以Ex组最低。联合治疗对降低血浆浓度有有益作用。在不改变血浆脂肪细胞因子的情况下，改善Zucker脂肪大鼠肝脏脂肪变性。观察ATV和Ex对自发性高血压大鼠（SHR）血压及内皮细胞和神经元NO合成酶（eNOS, nNOS）表达的影响。男性<SHR组随机分为4组；control组、ATV组、Ex组和ATV+ Ex组。8周后，与对照组相比，ATV、Ex和ATV +Ex组的收缩压（SBP）显著降低。ATV诱导肾皮质、髓质和胸椎eNOS蛋白表达。肾髓质和胸主动脉中存在nNOS蛋白。ex诱导eNOS蛋白在肾髓质特异性表达，nNOS蛋白在肾皮质、肾髓质和胸主动脉特异性表达。ATV和Ex在一定程度上通过诱导NOS蛋白阻止SHR高血压的发展，而NOS蛋白受Ex和ATV以不同的方式调节。

Effects of a combination therapy of the exercise training (Ex) and HMG-CoA reductase inhibitor, statin were determined. Male Zucker-fatty-rats were divided into four groups; a control, an atorvastatin (ATV), an Ex and a combination therapy (ATV+Ex) groups. After 10 weeks, the plasma glucose was not different in the ATV or the. Ex group, but it was lower in the ATV+Ex group than in the control group. The plasma total cholesterol was lower in the Ex and the ATV+Ex groups. The plasma triglyceride was lower in all three experimental groups. The plasma insulin, leptin and adiponectin were not significantly different among the four groups.-The hepatic triglyceride was lower in the Ex and the ATV+Ex groups, and the minimum levels were observed in the Ex group. The combination therapy has beneficial effects on reduction of the plasma. glucose and lipids and improvement of hepatic steatosis without the change of the plasma adipocytokines in Zucker fatty rats.Effects of ATV and Ex on: blood pressure and the expression of endothelial and neuronal NO synthase (eNOS, nNOS) in spontaneously hypertensive rats (SHR) were determined. Male <SHR were divided randomly into four groups; a control group, an ATV group, an Ex group, and a ATV+ Ex group. After 8 weeks, systolic blood pressure (SBP) was significantly lower in the ATV, Ex and ATV +Ex groups, compared with the control group. ATV induced eNOS protein in the renal cortex, medulla and thoracic. aorta, and nNOS protein in the renal medulla and thoracic aorta. Ex-induced eNOS protein specifically in the renal medulla, and nNOS protein in the renal cortex, medulla and thoracic aorta. ATV and Ex prevents the development of hypertension in SHR in part through the induction of NOS proteins, which is regulated by Ex and ATV in a different manner.