Effects of Lifestyle Factors on Clinical Outcomes of Prevention and Care of Diabetes

糖尿病和其他与生活方式有关的疾病是包括日本在内的大多数工业化国家的主要健康问题之一。近年来，其临床证据的必要性和重要性日益增加，这有助于制定策略和预防与护理。在本项目中，我们评估了饮食、运动、吸烟、饮酒等生活方式因素对与糖尿病和其他生活方式相关疾病的预防和护理相关的各种临床参数的影响。通过历史队列设计、荟萃分析等方法，可以建立许多重要的临床证据，并应用于临床。例如，我们可以发现吸烟是日本糖尿病患者患糖尿病肾病的一个非常重要的剂量依赖性风险因素。我们也可以阐明适当和合适的运动方式，以有效地提高HDL-胆固醇。这些结果在许多国际期刊上报道，如糖尿病护理，内科学年鉴等。

Diabetes mellitus and other lifestyle-related diseases are one of main health issues in most industrialized countries including Japan. Necessity and importance of their clinical evidences, which is useful in establishing strategies and for their prevention and care, are more and more increasing in these days. In this project, we evaluated effects of lifestyle factors such as diet, exercise, smoking, alcohol intake, etc. on various clinical parameters related to prevention and care of diabetes and other lifestyle-related diseases. By utilizing historical cohort design, meta-analysis and other methods, we could establish many important clinical evidences that could be applied in clinical settings. For example, we could find that smoking is a very important and dose-dependent risk factor for Japanese patients with diabetes to develop diabetic nephropathy. We could also clarify appropriate and suitable way of exercise for efficiently increasing HDL-cholesterol. Such results were reported in many international journals like Diabetes Care, Annals of Internal Medicine, and so on.