Development of molecular memory system usingpeptide molecules

在允许单个螺旋自由旋转的状态下，将螺旋连接到支架上，将多肽分散在水中，并将形成的单层转移到金上，无法获得多肽在金表面的STM图像，可能是因为多肽没有牢固地固定在表面。然后，将该多肽修饰为在每个螺旋的N端具有一个二硫键。将修饰后的多肽掺入十二烷基硫酸酯自组装单分子膜中。用扫描隧道显微镜对修饰后的多肽进行了观察。值得注意的是，修饰后的多肽随着施加在多肽上的偏置电压而在金上移动。然而，多肽的高度保持不变。通过三个点将多肽锚定在黄金上应该是固定恒定高度的原因。另一方面，利用环状β多肽构建了多肽纳米管。尽管环状β-多肽的单分子图像仍然不可能，但我们用原子力显微镜成功地观察到了多肽纳米管。我们试图从这些观察中找到获得单肽纳米管的条件。

Thee helices were connected to a scaffold in a state where free rotation of the individual helix was allowed The peptide was spread on water, and the formed monolayer was transferred on gold STM image of the peptide on gold could not be obtained, probably because the peptides were not immobilized on the surface firmly. Then, the peptide was modified to possess a disulfide group at the N terminal of each helix. The modified peptide was incorporated into the self-assembled monolayer of dodecanethiolate. The modified peptide was observed successfully by STM. Notably, the modified peptide moved on gold in response to the applied bias voltage on the peptide. However, the peptide height remained constant. Anchoring the peptide via three points to gold should be the reason fix the constant height. On the other hand, peptide nanotubes were constructed by using cyclic β-peptides. Even though a single molecule image of cyclic β-peptide was still impossible, we observed the peptide nanotubes successfully by AFM. We tried to find mite condition to obtain a single peptide nanotube from these observations.