Chemical state analysis of rarely contained biological metallic element using X-ray absorption fine structure (XAFS) analysis

在这项研究中，使用XAFS方法分析了生物组织中包含的金属元素和微小异物的化学状态，并对牙科和医用合金（如钛、镍钛合金、铬基合金）的行为进行了评价。钛在牙科和医用植入物周围组织中通常以金属钛的形式存在，但也可检出氧化钛。认为氧化钛来源于溶解和沉淀的Ti。镍以离子状态存在于镍基合金的周围环境中，因此，镍离子对周围组织的毒性作用受到关注。此外，还对样品中的微量元素（如硒）进行了分析，并对样品进行了XAFS分析。最后，提出了XAFS分析生物组织的可能性。

In this study, the chemical state of metallic elements and micro foreign bodies contained in the biological tissues were analyzed using XAFS method and the behavior of dental and medical alloys (e.g.titanium, nickel-titanium alloy, chromium-based alloy) was evaluated. Titanium in the surrounding tissues of dental and medical implants was usually existed as the metallic Ti, but, the titanium oxide was also detected. The titanium oxide was considered as derived from the dissolved and precipitated Ti. Nickel was existed as the ionic state in the surroundings of nickel-based alloy, then, the toxic effect of Ni ion to the surrounding tissues was concerned. In addition, trace element in the tussues (e.g.Se) analysis and micro XAFS analysis were also carried. In conclusion, the possibility of XAFS analysis for the biological tissue was suggested.