PREVENTIVE RESEARCH OF DIETARY ENVIRONMENT FACTORS WHICH ARE RELATED TO GENERATION AND PROGRESSION OF PROSTATE CANCER IN JAPANESE MALES

随着西化社会生活在日本的普及，前列腺癌的发病率和死亡率不断上升，迫切需要从分子预防的角度探讨微小隐匿性前列腺癌的进展与饮食环境因素的关系。本研究使用冷冻血清作为日本男性生活方式西化的指标，测量了残留物样颗粒-胆固醇(RLP-C)和RLP-甘油三酯(RLP-TG)。纳入本研究的25例前列腺癌患者，均经过至少3次连续筛查，基线PSA水平低于4 ng/ml(病例组)，25例非前列腺癌男性患者(对照组)参加了1992-2005年间的人群前列腺癌筛查。两组在初次筛查时和…最后一次筛查时用血清标本测定RLp-C和RLp-TG对照组较多，确诊时为病例组。病例组和对照组初筛时RLP-C平均水平分别为33.9 mg/dl和26.8 mg/dl，末次筛查时分别为27.6 mg/dl和20.8 mg/dl。两次筛查病例组血清RLP-Cs均值均高于对照组，但差异无统计学意义。病例组和对照组初筛时RLP-TG平均值分别为46.2 mg/dl和44.6 mg/dl，末次筛查时分别为48.6 mg/dl和39.1 mg/dl。在病例组中，平均血清RLP-TG水平从筛查开始到最后一次筛查都在上升，但在对照组中没有变化。然而，即使在最后一次筛查时，病例组和对照组之间的RLP-TG水平也没有显著差异。首次和末次筛查时RLP-C和RLP-TG在病例组和对照组之间均无显著差异，但仍可能提示血清残余脂蛋白持续升高与前列腺癌的发生有关。较少

Because the incidence and mortality rates of prostate cancer have increased with westernized-social life spreading in Japan, it is urgently needed to investigate the relationship between progression of minimal occult prostate cancer and dietary environment factors in the molecular preventive research point of view. The present study measured remnant-like particles-cholesterol (RLP-C) and RLP-triglyceride (RLP-TG) using frozen serum as an index to westemization of life-style in Japanese males. Twenty five cases diagnosed with prostate cancer after at least 3 consecutive screening with baseline PSA levels lower than 4ng/ml (case group) and age-adjusted and baseline-PSA-adjusted 25 men without prostate cancer (control group), who participated in the population-based screening for prostate cancer between 1992 and 2005, were enrolled in the present study. RLP-C and RLP-TG were measured using serum samples at the time of initial screening visit for both groups, at the last screening visit fo … More r control group and at the time of diagnosis for case group. The mean RLP-C levels in case and control groups, respectively, were 33.9mg/dl and 26.8mg/ml at the initial screening, and 27.6mg/dl and 20.8mg/dl at the last screening. The mean serum RLP-Cs in case group were higher than those in the control group at both screening visits, but there was no significant difference. The mean RLP-TG in the case and control groups, respectively, were 46.2 mg/dl and 44.6 mg/dl at the initial screening, and 48.6 mg/dl and 39.1 mg/dl at the last screening. The mean serum RLP-TG levels increased from initial to last screening in the case groups, but not did in the control groups. However, there was no significant difference in the RLP-TG levels even at the last screening between the case and control groups. The present study did not show significant differences in the serum RLP-C and RLP-TG between the case and control group both at the initial and last screening visits, the present study may still show the possibility of relationship between continuous increase in serum remnant lipoprotein and developing prostate cancer. Less