Next-generation dental resins which scavenge and immobilize endocrine disruptors by themselves

本研究的目的是发明新一代牙科树脂，这种树脂含有Bis-GMA，并且是绝对安全的。介绍了通过混合活性氧化铝填料抑制双酚A洗脱的基本技术。用高效液相色谱法对各种商品化的Bis-GMA单体进行了分析。单体的BIS-GMA含量约为50%，存在约25%的异构体Iso-Bis-GMA。因此，发现商品化的Bis-GMA单体含有约80%的Bis-GMA，包括异构体。结论：1.以氯仿为流动相对商品化的Bis-GMA进行硅胶柱层析处理，可得到纯度为20%~30%的Bis-GMA主组分。将纯Bis-GMA与共聚单体引发剂、填料复合，制备了化学固化和可见光固化树脂。固化树脂的各种性能表明，这对清除和固定双GMA复合材料中的双酚A等杂质非常有帮助。为了评价活性氧化铝填料对双酚A的自清除和自固定化性能，制备了大量不同组成的可见光固化复合树脂。通过在BIS-GMA复合材料中引入50wt%的碱性活性氧化铝，有效地清除和固定了双酚A。根据对固化树脂各项性能的测试，活性氧化铝的引入被证明是有效的，但仍有进一步改进的空间。

The aim of the present investigation was to invent next-generation dental resins which contain Bis-GMA and is absolutely safe. The fundamental techniques to suppress the bisphenol A elution by mixing activated alumina fillers with high bisphenol A-scavenging activity were presented.1. Various commercial Bis-GMA monomers were analyzed by HPLC. Bis-GMA content of the monomers was about 50 % and approximately 25 % of Iso-Bis-GMA, an isomer of Bis-GMA, was present. Therefore, it was found that commercial Bis-GMA monomers contained about 80 % of Bis-GMA including isomers. Pure Bis-GMA main component was obtained in 20 to 30 % yield by silica gel column chromatography treatment of commercial Bis-GMA using chloroform as mobile phase.2. Chemical-curing and visible-light-curing resins were prepared by combining pure Bis-GMA with comonomer initiator, and filler. Various properties of cured resins revealed that it is quite helpful to scavenge and immobilize impurities such as bisphenolA in a Bis-GMA composite.3. In order to evaluate self-scavenging and self-immobilizing performance for bisphenol A of activated alumina fillers, a lot of experimental visible-light-curing composite resins with different composition were prepared. Bisphenol A was effectively scavenged and immobilized by introducing 50 wt% of basic activated alumina into Bis-GMA composites. Based on the measurements of various properties of cured resins, the introduction of activated alumina was proved effective, although there is some room for further improvement.