The mechanism of abnormal secretion of saliva in patients with Sjogren's syndrome.

盐酸西维美林治疗干燥综合征对唾液腺轻度破坏者疗效显著。从SS模型小鼠制备的抗唾液腺单克隆抗体“nzm-1858”与人唾液腺导管细胞有反应，盐酸西维美林对nzm-1858免疫组化染色阳性的唾液腺更有效。针对nzm-1858的抗原是69 kDa蛋白，我们正在分析该蛋白。

Treatment with cevimeline hydrochloride in patients with Sjogren's syndrome is significantly effective to patients who had mild destruction of salivary glands. "nzm-1858", an anti salivary glands monoclonal antibody established from model mice of SS, reacts to human salivary ductal cells, and cevimeline hydrochloride is more effective to salivary glands which have positive reaction to nzm-1858 in immunohistchemical staining. Antigen to nzm-1858 is 69kDa protein and we are analyzing this protein.