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Establishment of the new mouse model of Sjogren's syndrome and detection of their autoantigens.

新型干燥综合征小鼠模型的建立及其自身抗原的检测。

基本信息

批准号：
14571790
负责人：
OHYAMA Yukiko
金额：
$ 2.24万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571790/
关键词：
Sjogren's syndrome model mouse autoantigens 自己免疫疾患サイトメガロウイルス

项目摘要

Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration and ductal destruction in salivary glands (SG) and lacrimal glands (LG). Its cause remains unknown although viral infection has been implicated to play an initiating role. NZM2328 mice, which are murine model of SLE, were inoculated intraperitoneally with MCMV and induced sialoadenitis at 100 days after inoculation despite the absence of detectable MCMV. Histological findings and the production of autoantibodies against Ro60, Ro52 and La were similar to SS. Anti-SG and anti-LG ductal antibodies were also detected and autoantibodies against exocrine glands were detected from their sera. 67kDa of proteins, which were DNAK type molecular chaperone and cytokeratin, were the candidates of one of the autoantigens. These results indicate that acute inflammation by MCMV infection trigger chronic sialoadenitis in autoimmune-prone mice with female predominance, establishing a new model useful to study the pathogenesis of SS regarding the initiation of autoimmunity by common pathogens and to find out their autoantigens are useful to treatment for the patients with SS.

干燥综合征（SS）是一种以唾液腺（SG）和泪腺（LG）淋巴细胞浸润和导管破坏为特征的自身免疫性疾病。其原因仍然不明，虽然病毒感染已被牵连发挥启动作用。将SLE小鼠模型NZM2328小鼠腹腔接种MCMV，尽管没有检测到MCMV，但在接种后100天诱导了涎腺炎。组织学结果和对Ro60，Ro52和La的自身抗体的产生与SS相似。还检测到抗SG和抗LG导管抗体，并从其血清中检测到抗外分泌腺的自身抗体。67kDa的蛋白质为DNAK型分子伴侣蛋白和细胞角蛋白，是自身抗原的候选抗原之一。这些结果表明，MCMV感染的急性炎症触发慢性涎腺炎的自身免疫易感小鼠，女性占主导地位，建立一个新的模型，有助于研究SS的发病机制，从常见的病原体启动自身免疫，并找出其自身抗原是有用的SS患者的治疗。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Multiple sialolithiasis in the parotid gland with Sjogren's syndrome and its sonographic findings--report of 3 cases.

干燥综合征腮腺多发唾液石症及其超声表现——附3例报告。

DOI：
发表时间：
2005
期刊：
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99(1)
影响因子：
0
作者：
Fukushima H;Kajiya H;Okamoto F;Jimi E;Motokawa W;Okabe K.;Pal R Pal R et al.;山村健介;Shimizu M et al.
通讯作者：
Shimizu M et al.

Accumulation of oligoclonal T cells in the infiltrating lymphocytes in oral lichen planus