The Structure Function and Biology of Serpins

在多种生物系统中，丝氨酸蛋白家族通过显著的构象变化来控制蛋白水解酶活性。我们是蛇针研究领域的四个领导者，使用生物化学、生物物理学、分子生物学、细胞生物学、结构生物学和生物信息学的综合方法来分析蛇针的结构、功能和生物学的方方面面。我们将应用和开发新技术，这些技术将决定如何实现这些构象变化以及如何控制它们。我们对这种抑制物-酶相互作用的深入了解将对其他经历构象变化和生物技术的蛋白质产生影响。

The serpin family of proteins control protease activity, in a variety of biological systems, via a dramatic conformational change. We are 4 leaders in the serpin reseacrh field using an integrated approach of biochemistry, biophysics, molecular biology, cell biology, structural biology and bioinformatics to analyse every facet of serpin structure, function and biology. We will apply and develop novel technologies that will determine how these conformational changes are achieved and how they are controlled. Our increased understanding of this inhibitor - enzyme interaction will have implications to other proteins which undergo conformational change and biotechnology.