Osmoregulatory MAP kinase signal transduction pathway

当暴露于高渗透压环境中时，出芽酵母酿酒酵母激活Hog1 MAP激酶信号通路，该信号通路控制着一系列适应性反应。在这个项目中，我们研究了两个新发现的渗透传感器Hkr1和Msb2如何调节Hog1 MAPK通路的活性。我们还研究了膜锚蛋白Opy2、膜蛋白Sho1和衔接蛋白Ste50在Hog1 MAPK通路动态调控中的作用。

When exposed to environmental hyperosmolarity, the budding yeast Saccharomyces cerevisiae activates the Hog1 MAP kinase signal pathway, which governs an array of adaptive responses. In this project, we investigated how the activity of the Hog1 MAPK pathway is regulated by the two newly discovered osmosensors Hkr1 and Msb2. We also investigated the roles of the membrane anchor protein Opy2, membrane protein Sho1, and the adaptor protein Ste50 in dynamic regulation of the Hog1 MAPK pathway.