Investigation of linkage between histone modification and DNA damage after irradiation

这项研究清楚地表明，组蛋白调节，特别是通过SUV 420 H2敲低抑制组蛋白H4中赖氨酸20处的组蛋白甲基化，可以增加放射敏感性。此外，我们还研究了DNA DSB的修复能力如何影响癌症易感性以及肿瘤和正常组织的放射敏感性，重点是5-氯-2，4-二羟基吡啶（吉美拉西）和DNA-PK的活性。这些可能有助于建立一种新的放射治疗。

This study clearly demonstrates that histone modulation, especially inhibition of histone methylation at lysine 20 in histone H4 via SUV420H2 knockdown, can increase radiosensitivity. Also, we have investigated how the ability of repair of DNA DSB influences cancer susceptibility and the radiosensitivity of tumors and normal tissues by focusing on the activity of 5-chloro-2, 4-dihydroxypyridine (Gimeracil) and DNA-PK. These may be useful for establishment of a novel radiotherapy.