New strategy for the enhanced chemosensitivity and less metastatic potential of ovarian cancer targeting EMT inducible transcriptional factor

我们证明了EMT和EMT诱导转录因子在卵巢癌转移中的意义。此外，TWIST，EMT诱导因子之一，积极影响腹膜转移的形成或抗肿瘤药物的耐药性在这种肿瘤。此外，即使在复发性卵巢癌中，我们也显示了EMT与局部转移潜能增加之间的可能联系。本研究提示EMT诱导因子靶向治疗可能为难治性卵巢癌的治疗开辟一条新途径。

We demonstrated the significance of EMT and EMT inducible transcriptional factor in the metastasis of ovarian cancer. In addition, TWIST, one of the EMT inducible factors positively influenced the formation of peritoneal metastasis or the resistance to anti-neoplastic agents in this tumor. Furthermore, even in the recurrent ovarian cancer we showed the possible link between EMT and increasing local metastatic potential. Our study suggested the EMT inducible factor targeting therapy may lead to a new approach for the treatment of refractory ovarian cancer.