Structural elucidation and functional analysis of insulin-like growth factor binding protein-3 domains

在后基因组时代，将人类基因组计划中的信息转化为细胞功能信息是一项重大挑战。多功能胰岛素样生长因子结合蛋白-3 （IGFBP-3）是一个多基因超家族的成员，通过多种信号通路调节细胞生长和功能。该项目将提供关于IGFBP-3的结构信息，作为超家族的原型，并使用多种方法的组合将揭示IGFBP-3的作用机制。该项目将促进对IGFBP-3及其超家族功能的了解，并在动物和人类生长和代谢方面提供国际研究领导地位和经济和健康效益。

Translating information from the human genome project into information about cell function is a major challenge in the post-genome era. The multifunctional insulin-like growth factor binding protein-3 (IGFBP-3), a member of a multigene superfamily, regulates cell growth and function through numerous signalling pathways. This project will provide structural information about IGFBP-3 as a prototype for the superfamily, and using a combination of methodologies will unravel mechanisms of IGFBP-3 action. The project will advance understanding of IGFBP-3 and superfamily functions, and provide both benefits in international research leadership and economic and health benefits in animal and human growth and metabolism.