Study of environmental stress responses using amphiphiles

局部麻醉剂和抗精神病的吩噻嗪类药物导致酵母中肌动蛋白极化和翻译起始的快速关闭。本文研究了多种两亲体的构效关系。亲水性区域的结构、疏水性区域的长度以及这两个区域的结构分别决定了关闭模式、效力和安全性。这些结果表明，酵母系统可以方便地对临床药物进行评价，并为设计关断化合物提供结构依据。

Local anesthetics and antipsychotic phenothiazines cause rapid shutdowns of both actin polarization and translation initiation in yeast. Here we investigated the structure-activity relationship using a variety of amphiphiles. Structure of hydrophilic region, length of hydrophobic region, and structures of both regions were responsible for the shutdown pattern, potency, and safety, respectively. These results indicate that the yeast system can easily evaluate the clinical drugs, and provide structural basis for designing shutdown compounds.