Mutations in genes encoding the K_<ATP> channel and their influence on efficacy of insulinotropic agents.

Kir6.2与SUR1共同形成一个ATP敏感的钾（K_<ATP>）通道，在胰腺细胞的胰岛素分泌中起关键作用。在本研究中，我们进行了包括电生理分析在内的功能分析，发现突变体在atp敏感性、磺脲敏感性和膜表面表达方面存在显著差异。此外，有可能通过体外分析来评估这些胰岛素药物对突变患者的潜在疗效。

Kir6.2, together with SUR1, forms an ATP-sensitive potassium (K_<ATP>) channel that plays a key role in insulin secretion from pancreatic ss-cells. In this study, we carried out functional analyses including electrophysiological analysis, and found significant differences in ATP-sensitivity, sulfonylurea-sensitivity, and membrane surface expression among the mutants. Furthermore, it is possible to evaluate the potential efficacy of these insulinotropic agents in patients with the mutation by using in vitro analyses.