The anesthetic effect at lidocaine iontophoresis using alternating currents with duty cycle

因此，使用离子电渗疗法（IOP）的局部麻醉压力较小，因为它既无痛又无创。我们评估了肾上腺素对利多卡因离子导入麻醉效果的影响。将含有肾上腺素的2%利多卡因溶液通过直流电离子导入法输送到肘前内侧皮肤。目前的研究表明，麻醉效果以肾上腺素剂量相关的方式显著增强，2%利多卡因与1：160，000肾上腺素的麻醉效果与1：80，000肾上腺素的麻醉效果相当，但在临床情况下报告了一些不良反应，包括因IOP使用直流电而导致的电灼伤或红斑。这些不利的副作用限制了DC-IOP在低至1 mA/cm 2的电流密度下的应用时间小于15 min。我们评估了在利多卡因离子导入过程中，交流电占空比对麻醉效果的影响。本研究表明，麻醉效果显着增强占空比依赖的方式。

Local anesthesia using iontophoresis(IOP) is therefore less stressful because it is both painless and non-invasive. We assessed the effect of epinephrine on the anesthetic effect during lidocaine iontophoresis. A solution of 2% lidocaine with epinephrine was delivered to the medial antecubital skin by iontophoresis direct current. The present study revealed that the anesthetic effect was significantly enhanced in an epinephrine dose-related manner and the anesthetic effect of 2% lidocaine with 1:160,000 epinephrine was equivalent to the same anesthetic with 1:80,000 epinephrine.However, some adverse effects, including electrical burns or erythema resulting from IOP use of direct current, were reported in clinical situations. These unfavorable side-effects restrict the application time of DC-IOP less than 15 min at current densities as low as 1 mA/cm2. We assessed the effect of duty cycle in the alternative current on the anesthetic effect during lidocaine iontophoresis. The present study revealed that the anesthetic effect was significantly enhanced in duty cycle dependent manner.