Studies on the mechanisms of regulation of catecholamine release in the nucleus accumbens

口腔运动障碍是一种神经系统综合征，与衰老或使用帕金森病药物和抗精神病药物有关。该疾病的生物学基础尚不清楚，但药物行为学研究表明，伏隔核和纹状体多巴胺功能的增强对诱导大鼠的重复性下颌运动起关键作用。因此，在本研究中，我们利用活体脑微透析技术研究了自由运动大鼠伏隔区和纹状体多巴胺能活性增加的机制。

Oral dyskinesia is a neurological syndrome associated with aging or use of drugs for Parkinson's disease and antipsychotics. It is characterized by repetitive stereotyped oral movement The detaned biological basis of the disorder remains unclear, but the phamaco-behavioural studies suggest that enhance of dopamine function in the nucleus accumbens and striatum plays a pivotal role for the induction of repetitive jaw movements of rats. Therefore, in the present study, we nvestigated the mechanisms of increase in accumbal and striatal dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.