The induction mechanism of new bone formation by sintered carbonate apatite grafted into bone

植入大鼠骨内1个月后，烧结的碳酸磷灰石被成纤维细胞样细胞、成骨细胞样细胞和/或多核巨细胞覆盖。虽然部分烧结的碳酸磷灰石被多核巨细胞或巨噬细胞吸收，但在存活的碳酸磷灰石表面附近，观察到宽度约100 nm的中等电子致密层，其中经常形成新骨。在该层上检测到代表硫酸化糖缀合物或硫酸化糖蛋白的小类型HID-TCH-SP染色沉积物。

The sintered carbonate apatite grafted into rat bone at one month after implantation was coated with fibroblast-like cells, osteoblast-like cells, and/or multi-nucleated giant cells. Although part of the sintered carbonate apatite was absorbed by multinucleated giant cells or macrophages, adjacent to the surface of the survived carbonate apatite, moderate electron dense layer of about 100nm in width, was observed, where newly formed bone was frequently formed. Small type of HID-TCH-SP stain deposits that represent sulfated glycoconjugates or sulfated glycoproteins were detected over the layer.