Organization and basic functional mechanism of cerebellar modules

小脑模块由浦肯野细胞、爬行纤维和苔藓纤维的分子表达模式和输入-输出轴突连接组成。我们将浦肯野细胞和苔藓纤维轴突的轴突连接与醛缩酶C的表达模式联系起来。结合我们之前关于爬行纤维投射模式的结果，我们阐明了小脑模块的组织，并展示了小脑输入和输出功能是如何在地形图上相关的。此外，通过分析绒猴的小脑和大鼠的小脑，我们还显示了啮齿动物和灵长类动物小脑模块化组织的相似性。

The cerebellar module is organized by the molecular expression pattern and input-output axonal connections of Purkinje cells, climbing fibers and mossy fibers. We related axonal connections of Purkinje cells and mossy fiber axons that originate from the dorsal column nuclei to the aldolase C expression pattern. Combining the results with our previous findings on the climbing fiber projection pattern, we clarified the organization of cerebellar modules, and show how cerebellar input and output functions are correlated topographically. Furthermore, we have shown similarity of the cerebellar modular organization between rodents and primates by analyzing the marmoset cerebellum in addition to the rat cerebellum.