Elucidation of immunoregulatory function of intestinal immunoregulatory cells and its application to anti-infectious and anti-allergic food

本研究试图阐明肠道调节细胞的免疫调节功能。这对开发新型免疫功能食品具有重要意义。我们检测了肠道免疫器官派伊尔集合淋巴结（Peyer's patch）的树突状细胞对微生物成分的反应，分析了肠道中独特的细胞群CD 3 ^-IL-2 R ^+细胞的特性，并建立了感染小鼠模型。我们进一步阐明了两种类型的调节性T细胞在口服耐受中诱导的功能，这是食物过敏的抑制机制，并证明了树突状细胞在其诱导中的作用。

In this study, we tried to elucidate the immune regulating functions of intestinal regulatory cells . This should be important in the development of novel immune functional foods. We examined the response of dendritic cells of Peyer's patch, an intestinal immune organ, to microbial components, analyzed the characteristics of CD3^-IL-2R^+ cells, a unique cell population in the intestine, and established an infection mouse model. We further elucidated the function of two types of regulatory T cells induced in oral tolerance, which is a suppressive mechanism of food allergy, and demonstrated the role of dendritic cells in its induction.