Clinocopathological analysis of HTLV-I associated genes of HBZ and tax in the tumor genesis of ATLL

成人t细胞白血病/淋巴瘤（ATLL）是一种与人t细胞白血病病毒1型（HTLV-1）相关的t细胞恶性肿瘤。HTLV-1原病毒基因组具有编码税基和HTLV-1碱性亮氨酸拉链因子（HBZ）的pX区。先前的研究报道，tax基因在少数ATLL病例中表达，而HBZ基因在所有ATLL病例中表达。在本研究中，hbz在所有ATLL细胞系和ATLL模型小鼠以及人ATLL病例中均有表达。但是，“Tax”的表达非常罕见。此外，我们分析了调节性T细胞的关键分子FOXP3的表达。大约三分之一的ATLL中检测到该表达。FOXP3的表达与免疫抑制状态有关。

Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy associated with human T-cell leukemia virus type 1 (HTLV-1). The HTLV-1 provirus genome has the pX region which encodes tax and HTLV-1 basic leucine zipper factor (HBZ). The previous studies have reported that the tax gene is expressed in few ATLL cases, but the HBZ gene in all ATLL cases. In this study, HBZ-expression was demonstrated in all cases of ATLL cell line and ATLL model mouse, and human ATLL cases. However, Tax expression was rare. In addition,we analyzed the expression of FOXP3, a key molecule of regulatory T cells. The expression was detected in about one third of ATLL. And FOXP3 expression is associated with an immunosuppressive state.