Analysis and risk assessment of diffuse gastric cancer based on inflammation-induced epigenetic alterations

在本研究中，我们分析了与幽门螺杆菌（H.pylori）诱导的胃癌发生相关的异常DNA甲基化。我们的研究表明，在弥漫性胃癌癌前病变中，癌相关基因的CpG岛高甲基化和整体低甲基化均存在。此外，通过全基因组筛选，我们已经确定了新的胃癌相关基因和microRNA的异常DNA甲基化。功能分析表明这些基因是胃癌的候选抑癌基因，临床样本中的DNA甲基化分析表明这些基因可能是有用的胃癌风险标志物。

In the current study, we have analyzed for aberrant DNA methylation which is associated with Helicobacter pylori (H.pylori) induced gastric carcinogenesis. We have shown evidences that both CpG island hypermethylation of cancer-related genes and global hypomethylation occurs in premalignant lesions of diffuse gastric cancer. In addition, through genome-wide screening, we have identified aberrant DNA methylation of novel gastric cancer-related genes and microRNAs. Functional analysis revealed that these are candidate gastric cancer suppressor genes, and DNA methylation analysis in clinical samples suggested that these could be useful risk markers of gastric cancer.