Demonstration of PACAP on protection of delayed neuronal cell death and its molecular mechanism of neuroregeneration.

我们研究阐明了PACAP对小鼠脑缺血后延迟性神经元细胞死亡的保护作用的分子基础，并对人类进行了转化研究。此外，我们还研究了PACAP刺激神经干细胞向神经元和/或神经胶质细胞分化的分子机制。此外，我们还开发了一种新的经鼻输注的PACAP给药系统（DDS），以保护脑缺血后延迟性神经元细胞死亡。本研究将对脑缺血的保护产生重要影响，为新开发的DDS脑缺血后神经退行性疾病患者临床应用PACAP及其相关肽开辟了新的途径。

We have studied to clarify the molecular basis for PACAP on protection of delayed neuronal cell death after brain ischemia in mice and to make a translational study for humans. I n addition, we have also studied the molecular mechanism of PACAP on stimulating differentiation from neural stem cells into neurons and/or glial cells. Moreover, we developed a new drug delivery system (DDS) of PACAP by use of intranasal infusion to protect delayed neuronal cell death after brain ischemia. The present study will have a strong impact for protection of brain ischemia and it will open a new avenue to use of PACAP and its related peptides for clinical use for patients who will be suffered from neurodegeneration after brain ischemia with a new developed DDS.