Development and Assessment of tomosynthesis reconstruction algorithm based on refraction contrast

介绍了一种基于劳-格分析仪的软组织断层合成成像系统。由于该成像系统通过对前衍射和衍射方向同时获得的投影进行折射获得角偏差，因此与传统的衍射增强成像（DEI）方法相比，测量时间和所需的辐射剂量减少了一半。此外，本文提出的基于测量过程中定量关系的重建算法，尽管辐射剂量仅为折射对比CT成像的十分之一，但从形态学成像的角度来看，所生成的图像丝毫不逊色于折射对比CT图像。我们使用KEK中垂直摆动波束线PF-BL14C构建的系统对从人体切除的肺组织样本进行离体成像，以证明所提出的成像方案的有效性。

A novel tomosynthesis imaging system for soft tissues using Laue-case analyzer is described. Since the imaging system obtains angular deviation by refraction from the projections simultaneously acquired in forwardly diffracted and diffracted directions, the measurement time as well as the radiation dose required decreases by one half compared to the conventional diffraction enhanced imaging (DEI) method. In addition, the proposed reconstruction algorithm derived from the quantitative relationship in measurement process produces images in no way inferior to refraction-contrast CT images from the viewpoint of morphological imaging in spite of one tenth the radiation dose of refraction-contrast CT imaging. We ex vivo imaged a lung tissue sample excised from a human using the system constructed at the vertical wiggler beamline PF-BL14C in KEK to demonstrate the efficacy of the proposed imaging protocol.