Sonodynamic cancer therapy-the combination effects of an anticancer drug and a sonosensitizer

低强度超声辐照与声敏剂（声动力疗法，SDT）是一种有前途的候选人用于癌症治疗，因为更深的组织穿透能力比光和光毒性比光动力疗法与光敏剂。为了开发SDT，DEG，一种新的声敏剂，进行了表征和评估。此外，在体外和体内评估抗癌药物和DEG对SDT的组合作用。在小鼠异种移植瘤模型中观察到了DEG与抗癌药物的协同抗肿瘤作用，并且在体外细胞毒性试验中观察到了DEG与抗癌药物联合超声照射的协同抗肿瘤作用，这表明DEG与抗癌药物联合的SDT可能是一种有用的癌症治疗方法。

Low-intensity ultrasound irradiation with a sonosensitizer (sonodynamic therapy, SDT) is one of the promising candidates for cancer therapy because of the deeper tissue penetrating ability than light and lower phototoxicity than photodynamic therapy with a photosensitizer. In order to develop SDT, DEG, a novel sonosensitizer, was characterized and assessed. Furthermore, Combinational effect of an anticancer drug and DEG on SDT was evaluated both in vitro and in vivo. The synergistic antitumor effect was observed in mouse xenograft model as well as in vitro cytotoxic assay in combination of DEG and anticancer drug on ultrasound irradiation, suggesting that the SDT in combination of DEG and anticancer drug might be a useful treatment for cancer.