The prodrug action and its function of tocotrienol in vivo.

已知γ-生育酚和γ-生育三烯酚（维生素E类似物之一）在体内被代谢为γ-羧乙基羟基色满（γ-CEHC）。另一方面，γ-CEHC具有将钠排泄到大鼠尿液中的生理活性。本研究进一步研究了γ-生育酚和γ-生育三烯酚的前药作用和γ-CEHC的体内合成。因此，很明显γ-生育三烯酚比γ-生育酚更多地代谢为γ-CEHC。此外，这表明，它可能存在的功能域的前药作用的维生素E类似物。

It is knouwn thatγ-Tocopherol and γ-tocotrienol, one of the vitamin E analogs, are metabolized to γ-carboxyethyle-hydoroxychroman (γ-CEHC) in vivo. On the other hands, γ-CEHC has the physiological activity for sodium excretion into rat urine. Then, this study was further investigated on the pro-drug action and the production of γ-CEHC fromγ-tocopherol and γ-tocotrienol in vivo. Consequently, it is clear that γ-tocotrienol is metabolized to γ-CEHC more than γ-tocopherol. Moreover, it is suggested that it may exist the functional domain on the pro-drug action of vitamin E analogs.