Construction of Topological Supramolecules Utilizing Complementary Salt Bridge Formation and Their Application

设计并合成了一种具有可控螺旋感觉的杂链双螺旋结构，它是由光学活性的二聚酰胺及其带有共轭二乙基苯骨架的互补非手性二羧酸链通过盐桥稳定而成。在光学活性的酰胺二聚体的存在下，一端带有氨基或甲酰基的羧酸衍生物在苯中的二聚反应显著增强，得到了盐桥稳定的互补双螺旋。利用酰胺-羧酸盐桥，合成了具有光学活性的[2]环戊二烯。这两个大环组分的相对运动完全由酸/碱或锌离子/密码控制。

A hetero-stranded double helix with a controlled helix sense was designed and synthesized from an optically active dimeric amidine and its complementary achiral dicarboxylic acid strand with conjugated m-diethynylbenzene backbones, being stabilized by the salt bridges. The dimerization of carboxylic acid derivatives bearing an amino or a formyl group at one end was significantly enhanced in benzene in the presence of an optically active amidine dimer to afford a complementary double helix stabilized with salt bridges. An optically active [2]catenane was synthesized by utilizing amidinium-carboxylate salt bridge. The relative motion of the two macrocyclic components was completely controlled by an acid/base or Zn^<2+>/cryptand control.