The Physiological function of V-ATPase involved in membrane traffick

膜腔内的酸化是所有真核细胞的共同特征。由v - atp酶产生的酸性环境参与了许多生理过程，包括分泌、蛋白质加工等。通过亚单位特异性敲除小鼠，我们发现V-ATPase的功能参与胰岛素分泌、出生吸收和巨噬细胞功能。我们还发现（原）肾素受体是v - atp酶复合物的一个组装因子。

Acidification inside membrane compartments is a common feature of all eukaryotic cells. The acidic milieu, generated by the V-ATPase, is involved in many physiological processes including secretion, protein processing, and others. Using subunit-specific knockout mice, we have shown that the function of V-ATPase is involved in insulin secretion, born resorption and macrophage functions. We have also revealed that the (pro)renin receptor functions as an assembly factor of the V-ATPase complex.