The molecular mechanism underlying the co-regulation of plasma membrane and F-actin

细胞在各种生理条件下改变其形态。这些变化需要质膜和细胞骨架的共同调节，其机制尚不完全清楚。我们通过对SWAP-70的功能分析解决了这个问题，SWAP-70以刺激依赖的方式与膜和肌动蛋白结合。我们发现SWAP-70与整合素结合。1，以及整联蛋白的活化。1挽救了SWAP-70缺陷型，表明SWAP-70可能通过激活整合素发挥作用。1、通过互动

Cells change their morphology under various physiological conditions. Co-regulation of plasma membrane and cytoskeleton is required for these changes, the mechanism of which is not fully understood. We addressed the issue by functional analysis of SWAP-70, which binds to both membrane and actin in a stimulus-dependent way. We found that SWAP-70 binds to integrin. 1 in a pull down assay, and the activation of integrin. 1 rescued SWAP-70-deficient phenotype, suggesting that SWAP-70 may function by activating integrin. 1 through their interaction.