Development of novel chemical libraries for drug discovery based on the oligosaccharides moieties of significant bio-active glycosides.

在包括番茄叶和茎在内的番茄植株体中，一种类固醇生物碱“番茄素”是所有成分的主要成分。以番茄素为原料，在丙炔醇存在下，利用端糖苷酶“番茄酶”制备丙炔基番茄四苷。我们在丙炔基糖四苷和叠氮基苷元部分合成了几个与乙炔偶联的糖四苷基衍生物。该合成方法简单有效，可得到多种具有三唑环且不受番茄四苷中羟基保护的番茄四基衍生物。

In tomato plant bodies including leaves and stems, a steroidal alkaloid "tomatine" is the major ingredient of all. We prepared the propargyl lycotetraoside from the tomatine by using end-glycosidase "tomatinase" in the presence of propargyl alcohol. We applied to synthesize several lycotetraosyl derivatives coupled with an acetylene group in the propargyl lycotetraoside and azide groups in aglycone parts. The synthesis procedure is very simple and effective to get many kinds of lycotetraosyl derivatives having triazole ring without protection of hydroxyl group in lycotetraosides.