Metabonomics analysis of the metabolic syndrome model rats

我们认为，如果我们可以通过分析活体样品如尿液或血浆来确认代谢物从稳定状态发生变化，那么我们可以对患有生活方式相关疾病的代谢综合征模型大鼠进行代谢组学分析。因此，我们将目标挤压到磷酸盐化合物上，并制备分子聚合物（MIP）来压印以捕获磷酸盐化合物。我们将磷酸化合物应用于MIP的特异性识别，并通过选择性地提取靶分子而将其用于定量。这些结果表明，除了它们的形状识别，氢键相互作用可以发挥重要作用的保留和磷酸衍生物的分子识别能力。此外，分子印迹聚合物可成功地应用于特异性识别磷酸肽。

We thought that we were available to the metabolic syndrome model rat which had a lifestyle-related disease in what we cast a metabonomics analysis into if we could confirm that a metabolism thing changed from a steady state by analyzing living body samples such as urine or the plasma. Therefore we squeezed a target to a phosphate compound and prepared molecular polymer (MIP) to imprint to catch a phosphate compound. we applied to the specific recognition of the phosphate compound to MIP and used it for fixed-quantity by extracting a target molecule selectively. These results suggest that in addition to their shape recognition, hydrogen bonding interactions could play an important role in retentivity and molecular recognition ability of derivatives of phosphoric acid. Furthermore, the MIPs could be successfully applied to specific recognition of phosphopeptides.