Development of brain specific drug delivery system with microglia
Development of brain specific drug delivery system with microglia
批准号:
20590153
负责人:
MAEDA Tomoji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
在这项研究中,我们研究了小胶质细胞是否可以用于脑靶向给药系统,因为有报道说,小胶质细胞能够从血流进入大脑。首先,在我们的检测系统中,我们研究了核苷酸对小胶质细胞迁移的影响。我们发现三磷酸腺苷(ATP)、胸腺嘧啶核苷(TTP)和胞苷三磷酸(CTP)可诱导小胶质细胞迁移。
英文摘要
In this study, we investigated the possibility whether microglia can be used for brain-targeting drug delivery system, since it was reported that microglia is able to enter the brain from blood flow. At first, we studied the effect of nucleotides on the migration of microglia in our assay system. We found that adenosine triphosphate (ATP), thymidine triphosphate (TTP) and cytidine triphosphate (CTP) induced the migration of microglia.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.jsbmb.2010.06.014
发表时间:
2010-10-01
期刊:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
影响因子:
4.1
作者:
[Maeda, Tomoji, Irokawa, Masanori, Tamai, Ikumi]
通讯作者:
Tamai, Ikumi
Function analysis of endoplasmic reticulum stress inducible protein Herp focused on a calcium release in endoplasmic reticulum
-
批准号:26460100
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2014
-
负责人:MAEDA Tomoji
-
依托单位:
The development of new diagnostic and therapeutic tools for AD based on regulation of the gamma-secretase complex assembly.
-
批准号:23590110
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2011
-
负责人:MAEDA Tomoji
-
依托单位:
海外基金