Molecular-toxic and -pathological analyses for a synthetic narcotic, MDMA

在MDMA细胞水平和动物毒性研究中，对小鼠脑、心脏和肝脏中的mRNA分析、心血中的血清ALT分析以及心血中MDMA的毒理学分析进行了综合分析。行为异常小鼠心血中MDMA浓度低于行为异常培养细胞中MDMA浓度。小鼠血液中MDMA致死浓度约为异常细胞中MDMA致死浓度的1/2。在MDMA剂量为40 mg/kg体重时，通过mRNA因子和血清ALT水平分析表明肝脏中存在炎症。

In this study on toxicity of cell level and animals with MDMA, mRNA analyses in the brain, heart and liver of the mouse, serum ALT analysis of the heart blood, and toxicological analysis of MDMA in the heart blood are comprehensively analyzed. MDMA concentrations of heart blood in the mouse with abnormal action were lower than those added in the culture cells which had abnormal. MDMA lethal level in the blood of the mouse was about 1/2 level of that in the abnormal cells. In MDMA dose of 40 mg/kg body weight, inflammation in the liver was suggested by the analyses of mRNA factors and serum ALT level.