Immunological and genetic analysis of disease resistant native livestock

为了确定促进本地家畜疾病易感性的免疫和遗传因素，分析了细胞因子谱，并确定细胞因子基因是否存在多态性。我们发现，在抗病个体中，TNF-a和IFN-y的表达水平以及基因的启动子/预测增强子区域的转录活性高于易感个体。这些数据表明，这些发现至少在一定程度上有助于本地牲畜的抗病能力。

To attempt to identify immunological and genetic factors promoting the disease susceptibility in native livestock, cytokine profiles were analyzed, and then determined whether there are any polymorphisms in the cytokine genes. We found that the expression levels of TNF-a and IFN-y and transcription activities of the promoter/predicted enhancer region of the genes were higher in individuals with disease resistant than in susceptible individuals. These data suggest that the findings could at least in part contribute to the disease resistance in native livestock.