Effect of cognitive function mediated by NMDA receptor activation of new nootropic drug.

在本研究中，我们证明了奈非西坦通过激活CaM激酶II介导认知功能（Moriguchi et al.， J. Neurochem. 2008），奈非西坦通过激活嗅球化小鼠的CaM激酶II和PKC增加认知功能的损伤（Moriguchi et al.， J. Neurochem. 2009），奈非西坦通过大鼠皮质神经元突触前烟碱乙酰胆碱受体增强谷氨酸能系统（Moriguchi et al., neuroscience 2009）。加兰他明通过激活CaM激酶II介导认知功能（Moriguchi et al., Hippocampus, 2009）。

In this present study, we demonstrated that nefiracetam mediates cognitive function through activation of CaM kinase II (Moriguchi et al., J. Neurochem. 2008), and nefiracetam augments the impairment of coginitive function through activation of CaM kinase II and PKC in olfactory bulbectomized mice (Moriguchi et al., J. Neurochem. 2009), and nefiracetam enhances glutamatergic system via presynaptic nicotinic acethylcholine receptors in rat cortical neurons (Moriguchi et al., Neuroscinece 2009), and galantamine mediates cognitive function through activation of CaM kinase II (Moriguchi et al., Hippocampus, 2009).