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Analysis of cytokine secretion and its application using macrophage specific syntaxin 3 knockout mice

Analysis of cytokine secretion and its application using macrophage specific syntaxin 3 knockout mice
巨噬细胞特异性突触蛋白3基因敲除小鼠细胞因子分泌分析及其应用
批准号:
20791063
负责人:
IRIUCHIJIMA Nobuhisa
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
翻译
采用巨噬细胞特异性syntaxin 3基因敲除小鼠,通过染色和ELISA检测syntaxin 3是否参与TNFα的分泌。与最初的估计不同,syntaxin 3未被发现参与TNFα的分泌。然而,syntaxin 3从高尔基体移动到细胞外周,人们认为它参与了其他细胞因子的分泌。
英文摘要
Using macrophage specific syntaxin 3 knockout mice, whether syntaxin 3 was involved in the secretion of TNFα, it was evaluated by staining and ELISA. Unlike the initial estimates,the syntaxin 3 was not found to be involved in the secretion of TNFα. However, syntaxin 3 to move from the Golgi apparatus to the cell periphery, It was thought it is involved in the secretion of other cytokines.
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