Physical Outcomes and Nursing of Patients with Amyotrophic Lateral Sclerosis Using Long-Term Home Mechanical Ventilation

我们研究了肌萎缩侧索硬化症（ALS）的症状，其发病机制，以及长期接受家庭机械通气的ALS患者的治疗策略。症状包括与共济失调相关的继发性障碍、情绪/自主运动系统紊乱、呼吸机/卧位相关并发症和其他涉及全身的并发症。详细的检查很困难，由于患者无法表达自己，无法评估症状及其等级，因此治疗困难。为了保持沟通能力，我们设计了一种方法来检测生命信号和精细的肌肉活动使用括约肌，其功能已被病理报告保留。

We investigated symptoms of amyotrophic lateral sclerosis (ALS) other than those previously reported, its pathogenesis, and therapeutic strategies in ALS patients receiving long-term home mechanical ventilation. The symptoms included secondary disturbance related to dystaxia, disorder of the emotional/autonomic movement system,respirator-/recumbency-related complications, and other complications, involving the whole body. Detailed examination was difficult, and it was impossible to evaluate symptoms and their grade due to the patients' inability to express themselves, making treatment difficult. To maintain the communicative ability, we devised a method to detect vital signals and fine muscle activities using the sphincter, whose function has been pathologically reported to be retained.