Role of DNAM-1 (CD226) in rapid progressive glomerulonephritis

DNAM-1 （CD226）是一种粘附分子，在大多数NK细胞、T细胞、单核细胞和血小板上表达，在物理和功能上与白细胞功能相关抗原-1 （LFA-1）相关。脊髓灰质炎病毒受体（PVR） CD155及其家族成员CD112 （PVR相关家族2 (pr -2)，也称为连接素-2）是人和小鼠DNAM-1的配体。我们用抗肾小球基底膜抗体分析了野生型小鼠和DNAM-1 （CD226）基因缺陷小鼠的快速进展性肾小球肾炎。我们将野生型小鼠与dnam1基因缺失小鼠进行比较，发现肾炎程度较弱。提示DNAM-1可能与快速进行性肾小球肾炎的发生有关。

DNAM-1 (CD226) is an adhesion molecule expressed on the majority of NK cells, T cells, monocytes and platelets and physically and functionally associates with leukocyte function-associated antigen-1 (LFA-1). The poliovirus receptor (PVR) CD155 and its family member CD112 (PVR-related family-2 (PRR-2), also called as nectin-2) are ligands for human and mouse DNAM-1. We analyzed rapid progressive glomerulonephritis for wild type mouse and DNAM-1 (CD226) gene deficit mouse using antiglomerulus basement membrane antibody. We compared wild type mouse with the DNAM-1 gene deficit mouse, and the degree of the nephritis was showed weakly. The possibility that DNAM-1 related with the onset of the rapid progressive glomerulonephritis was suggested.