Structural and functional analyses of the mirror neuron system and their application to early diagnosis in schizophrenia

一项弥散张量成像（DTI）研究显示，在连接额叶、丘脑和颞叶的束中，白质完整性受到干扰，其中一部分被认为与精神分裂症的阴性症状有关。一项使用自我和他人评价任务的功能磁共振成像（fMRI）研究显示，精神分裂症患者的前额叶皮层、大脑中线结构和顶叶下小叶存在功能异常，这为精神分裂症患者自我意识缺陷的神经基础提供了证据。一项早期精神病患者的结构MRI研究表明，前扣带皮层与精神分裂症患者显性精神病的表现有关。

A diffusion tensor imaging(DTI) study revealed disturbed white matter integrity in bundles connecting the frontal lobe with the thalamus and temporal lobe, a part of which is suggested to implicate the negative symptoms in schizophrenia. A functional magnetic resonance imaging(fMRI) study using self-and other-evaluation tasks demonstrated functional abnormalities in the prefrontal cortex, cerebral midline stuructures, and inferior parietal lobule, which provide evidence for neural basis of deficits in self-awareness in schizophrenia. A structural MRI study in patients with early phase of psychosis suggested the implication of the anterior cingulate cortex in manifestation of overt psychosis in schizophrenia.